Education and behavior have a greater impact on the development of nearsightedness than do genetic factors: With each school year completed, a person becomes more nearsighted. The higher the level of education completed, the more severe is the impairment of vision. These are the conclusions drawn by researchers at the Department of Ophthalmology at the Mainz University Medical Center from the results of the first population-based cohort study of this condition. A nearsighted eye is one in which the eyeball is too long in relation to the refractive power of the cornea and lens.
Body
Models for the evolution of life are now being developed to try and clarify the long term dynamics of an evolving system of species. Specifically, a recent model proposed by Petri Kärenlampi from the University of Eastern Finland in Joensuu accounts for species interactions with various degrees of symmetry, connectivity, and species abundance. This is an improvement on previous, simpler models, which apply random fitness levels to species.
A Coventry University scientist has developed a pioneering new way – using samples of beating heart tissue – to test the effect of drugs on the heart without using human or animal trials.
The breakthrough is the work of Dr Helen Maddock – an expert in cardiovascular physiology and pharmacology from the University's Centre for Applied Biological and Exercise Sciences – and could lead to the lives of hundreds of future patients being saved and the quality of their treatments improved.
With the sequence of the marmoset, the team revealed for the first time the genome of a non-human primate in the New World monkeys, which represents a separate branch in the primate evolutionary tree that is more distant from humans than those whose genomes have been studied in detail before. The sequence allows researchers to broaden their ability to study the human genome and its history as revealed by comparison with other primates.
The biology of twinning
Bread wheat (Triticum aestivum L.) is the most widely cultivated cereal crop in the world and provides 20 percent of the food calories consumed by humans. A polyploid species, hexaploid bread wheat contains six duplicated copies of its genome and is more than five times larger than the human genome. This makes genome research in wheat particularly difficult.
Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona have discovered the interaction between HERC2 proteins with another protein called p53 that is inactivated in more than half of human tumors. The study results were published in the Journal of Biological Chemistry.
Regulation of the activity of p53 by HERC2
The seriousness of disease often results from the strength of immune response, rather than with the virus, itself. Turning down that response, rather than attacking the virus, might be a better way to reduce that severity, says Juliet Morrison of the University of Washington, Seattle. She and her collaborators have now taken the first step in doing just that for the H7N9 influenza, and their work has already led to identification of six potential therapeutics for this highly virulent strain. The research is published ahead of print in the Journal of Virology.
A special class of tiny gold particles can easily slip through cell membranes, making them good candidates to deliver drugs directly to target cells.
A new study from MIT materials scientists reveals that these nanoparticles enter cells by taking advantage of a route normally used in vesicle-vesicle fusion, a crucial process that allows signal transmission between neurons. In the July 21 issue of Nature Communications, the researchers describe in detail the mechanism by which these nanoparticles are able to fuse with a membrane.
By tracking hybrids between songbird species, investigators have found that migration routes are under genetic control and could be preventing interbreeding. The research, which is published in Ecology Letters, was conducted using geolocators that, like GPS, record the position of a bird and allow its long distance movement to be tracked.
This is a songbird.
Men do not engage in riskier behaviors after they are circumcised, according to a study in Kenya by University of Illinois at Chicago researchers.
Three clinical trials have shown that male circumcision significantly reduces the risk of acquiring HIV in young African men. However, some experts have suggested that circumcision, if promoted as an HIV preventive, may increase promiscuity or decrease condom use. This 'risk compensation' could diminish the effectiveness of medical male circumcision programs.
A study of 473 sets of twins followed since birth found that compared to single-born children, 47 percent of 24-month-old identical twins had language delay compared to 31 percent of non-identical twins. Overall, twins had twice the rate of late language emergence of single-born children. None of the children had disabilities affecting language acquisition.
The results of the study were published in the June 2014 Journal of Speech, Language, and Hearing Research.
Among uncircumcised men in Kenya, compensation in the form of food vouchers worth approximately U.S. $9 or $15, compared with lesser or no compensation, resulted in a modest increase in the prevalence of circumcision after 2 months, according to a study published by JAMA. The study is being released to coincide with its presentation at the International AIDS Conference.
Salt Lake City – Woodrats lost their ability to eat toxic creosote bushes after antibiotics killed their gut microbes. Woodrats that never ate the plants were able to do so after receiving fecal transplants with microbes from creosote-eaters, University of Utah biologists found.
BOSTON – The most critical barrier for curing HIV-1 infection is the presence of the viral reservoir, the cells in which the HIV virus can lie dormant for many years and avoid elimination by antiretroviral drugs. Very little has been known about when and where the viral reservoir is established during acute HIV-1 infection, or the extent to which it is susceptible to early antiretroviral therapy (ART).
PHILADELPHIA -- In an analysis of small molecules called metabolites used by the body to make fuel in normal and cancerous cells in human kidney tissue, a research team from the Perelman School of Medicine at the University of Pennsylvania identified an enzyme key to applying the brakes on tumor growth. The team found that an enzyme called FBP1 – essential for regulating metabolism – binds to a transcription factor in the nucleus of certain kidney cells and restrains energy production in the cell body.