HOUSTON – (July 31, 2014) – Scientists have long speculated that mosaicism – a biological phenomenon, in which cells within the same person have a different genetic makeup – plays a bigger role in the transmission of rare disease mutations than is currently known. A study conducted by an international team of scientists led by Baylor College of Medicine sheds new light on the frequency of mosaicism in genomic disorders and its influence on recurrence risk.
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When goalkeepers are pitted against multiple kickers in tense penalty shootouts, their attempts to dive for the ball show a predictable pattern that kickers would do well to exploit. After kickers repeatedly kick in one direction, goalkeepers become increasingly likely to dive in the opposite direction, according to an analysis of all 361 kicks from the 37 penalty shootouts that occurred in World Cup and UEFA Euro Cup matches over a 36-year period.
The selective logging of trees in otherwise intact tropical forests can take a serious toll on the number of animal species living there. Mammals and amphibians are particularly sensitive to the effects of high-intensity logging, according to researchers in the Cell Press journal Current Biology on July 31 who conducted a meta-analysis of almost 50 previously published studies from around the world.
After a string of penalties aimed in the same direction, goalkeepers are more likely to dive in the opposite direction on the next penalty but kickers fail to exploit this pattern, finds new UCL research.
The study, published in Current Biology, shows that penalty shoot-outs in international tournaments resemble a psychological game. The researchers studied penalty shoot-out videos from all World Cup and Euro finals tournaments between 1976 and 2012.
While developing a new cancer drug, researchers at The Wistar Institute discovered that mice lacking a specific protein live longer lives with fewer age-related illnesses. The mice, which lack the TRAP-1 protein, demonstrated less age related tissue degeneration, obesity, and spontaneous tumor formation when compared to normal mice. Their findings could change how scientists view the metabolic networks within cells.
In what is believed to be the largest genetic analysis of what triggers and propels progression of tumor growth in a common childhood blood cancer, researchers at NYU Langone Medical Center report that they have identified a possible new drug target for treating the disease.
T-cell acute lymphoblastic leukemia is one of the most common and aggressive childhood blood cancers. An estimated quarter of the 500 adolescents and young adults diagnosed with the cancer each year in the U.S. fail to achieve remission with standard chemotherapy drugs.
DURHAM, N.C. – Harnessing a natural process in the body that pumps lethal doses of copper to fungi and bacteria shows promise as a new way to kill infectious microbes, a team of scientists at Duke University report.
Publishing in the July 31, 2014, issue of the journal Chemistry & Biology, the researchers describe a way of exploiting the unique chemical response from the body's immune system to attack pathogens using copper, long known for its antimicrobial properties, in a way that minimizes harm to the rest of the body.
CAMBRIDGE, Mass. (July 31, 2014) – Long associated with enabling the proliferation of cancer cells, the ancient cellular survival response regulated by Heat-Shock Factor 1 (HSF1) can also turn neighboring cells in their environment into co-conspirators that support malignant progression and metastasis.
The finding, reported by Whitehead Institute scientists this week in the journal Cell, lends new insights into tumor biology with significant implications for the diagnosis, prognosis, and management of cancer patients.
An experimental vaccine protected 100 percent of animal models against the highly infectious and virulent bacterium, Clostridium difficile, which causes an intestinal disease that kills approximately 30,000 Americans annually. The research is published ahead of print in Infection and Immunity.
In the study, the vaccine protected the mice and non-human primates against the purified toxins produced by C. difficile, as well as from an orogastric spore infection, a laboratory model that mimics the human disease, after only two immunizations.
Irvine, Calif., July 31, 2014 — Much of the liver's metabolic function is governed by circadian rhythms – our own body clock – and UC Irvine researchers have now found two independent mechanisms by which this occurs.
The study, published online today in Cell, reveals new information about the body clock's sway over metabolism and points the way to more focused drug treatments for liver disease and such metabolic disorders as obesity and diabetes.
WASHINGTON -- Everyone involved in the academic chemical research enterprise -- from researchers and principal investigators to university leadership -- has an important role to play in establishing and promoting a strong, positive safety culture, says a new report from the National Research Council. This requires a constant commitment to safety organization-wide and emphasis on identifying and solving problems, rather than merely adhering to a set of rules and assigning blame when those rules are not followed.
An international team of scientists from Spain, France, and the U.S. has discovered and described a rove beetle that is the oldest definitive member of the tribe Omaliini that has ever been found in amber. The discovery and description were made possible through the use of the propagation phase-contrast X-ray synchrotron imaging technique, which allows the detailed study of otherwise invisible specimens in opaque amber.
Since Alexandre Edmond Becquerel first discovered the photovoltaic effect in 1839, humankind has sought to further understand and harness the power of sunlight for its own purposes. In a new research report published in the August 2014 issue of the FASEB Journal, scientists may have uncovered a new method of exploiting the power of sunlight by focusing on a naturally occurring combination of lipids that have been strikingly conserved throughout evolution.
An important step has been made to help better identify and treat those with fibromuscular dysplasia (FMD). FMD causes both an abnormal narrowing and enlarging of medium sized arteries in the body, which can restrict blood flow to the kidneys and other organs causing damage. In a new report appearing in August 2014 issue of The FASEB Journal, scientists provide evidence that that FMD may not be limited to the arteries as currently believed.