Body

Philadelphia, December 10, 2020 - About five percent of patients experience heart muscle injury around the time of their surgery for a noncardiac condition, yet guideline recommendations to identify patients at risk using biomarkers are not being followed.

Scientists are continually searching for new and improved ways to deal with bacteria, be it to eliminate disease-causing strains or to modify potentially beneficial strains. And despite the numerous clever drugs and genetic engineering tools humans have invented for these tasks, those approaches can seem clumsy when compared to the finely tuned attacks waged by phages - the viruses that infect bacteria.

Each day, at least half a million Danes take a small pill to keep their blood pressure down or to protect against heart disease, and they should continue to take the medicine during the pandemic - even if the pill they take is an ACE inhibitor or Angiotensin II receptor blocker such as Losartan, Enalapril or Ramipril.

This is underscored by a new reassuring study, which, unlike all previous studies, also includes all Danes who have been tested for corona over a five month period - and not 'just' the most ill patients who have been hospitalised.

Postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has spread to a limited number of lymph nodes, and whose recurrence risk is relatively low, do not benefit from chemotherapy when it is added to hormone therapy, according to initial results from a clinical trial presented at the 2020 San Antonio Breast Cancer Symposium.

ANN ARBOR, Michigan -- Physicians did not recognize side effects from radiation therapy in more than half of breast cancer patients who reported a significant symptom, a new study finds.

Among patients in New York City with gynecologic cancer and COVID-19, Black patients younger than 65 years of age were five times more likely to require hospitalization than non-Blacks in the same age group. Even though Black patients with gynecologic cancer represented only one-third of patients in this study, they accounted for 41 percent of deaths due to COVID-19 when compared with non-Black patients.

Humans are more prone to develop carcinomas compared with our closest evolutionary cousins, the great apes. These cancers begin in the epithelial cells of the skin or the tissue that covers the surface of internal organs and glands, and they include prostate, breast, lung, and colorectal cancers. A new study published in FASEB BioAdvances reveals a human-specific connection between advanced carcinomas and a gene called SIGLEC12.

Although weight loss surgery is a highly effective treatment for obesity, it can be detrimental to bone health. A new study published in the Journal of Bone and Mineral Research suggests that exercise may help address this shortcoming.

The study randomized 84 patients undergoing weight loss surgery to an exercise group or a control group for 11 months. The exercise group performed high impact, balance, and resistance exercises three times per week.

SAN ANTONIO - Extended follow-up data from the phase III monarchE trial showed that adding the cyclin-dependent kinase (CDK) inhibitor abemaciclib (Verzenio) to standard adjuvant endocrine therapy continued to improve invasive disease-free survival (IDFS) among patients with high-risk, node-positive, early-stage, HR-positive, HER2-negative breast cancer, according to data presented at the 2020 San Antonio Breast Cancer Symposium, held Dec. 8-11.

SAN ANTONIO - Among patients with breast cancer treated with radiotherapy, under-recognition of symptoms was common in reports of pain, pruritus, edema, and fatigue, with younger patients and Black patients having significantly increased odds of symptom under-recognition, according to data presented at the 2020 San Antonio Breast Cancer Symposium, held Dec. 8-11.

SAN ANTONIO - Women who receive mastectomy and reconstructive surgery as part of breast cancer treatment may face the risk of developing persistent use of opioids and sedative-hypnotic drugs, according to data presented at the 2020 San Antonio Breast Cancer Symposium, held Dec. 8-11.

SAN ANTONIO - Older patients with hormone receptor-positive breast cancer who did not receive radiation therapy after breast-conserving surgery had higher rates of local recurrence but similar 10-year survival rates when compared to patients who received postoperative radiation therapy, according to updated 10-year data from the PRIME II study, presented at the 2020 San Antonio Breast Cancer Symposium, held Dec. 8-11.

The first human challenge trial to test COVID-19 treatments and vaccines is set to begin in January in the United Kingdom. These trials, in which healthy volunteers are infected with the virus after being given different vaccines under development, have sparked ethical debates around the benefits of developing a vaccine quickly and the risks of directly exposing people to coronavirus.

Blood tests for 'biomarkers' such as cholesterol and inflammation could predict whether you will be disabled in five years - according to research from the University of East Anglia.

A new study shows how people's biological health can predict disability and healthcare demand in five years' time.

But the researchers also found that people on higher-incomes were more likely to seek GP appointments and outpatient treatments for their medical problems - with evidence of pro-rich inequity across all types of health service use.

What The Study Did: Considering when health care resources need to be prioritized during special times, such as the COVID-19 pandemic, researchers in this observational study looked at whether delaying radical prostatectomy surgery for up to six months for high-risk prostate cancer was associated with worse outcomes.

Authors: Leilei Xia, M.D., of the University of Pennsylvania Perelman School of Medicine in Philadelphia, is the corresponding author.