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New treatments to cut the global death rate from dengue, Zika and West Nile viruses could result from research led by The University of Queensland.
Associate Professor Daniel Watterson from UQ's School of Chemistry and Molecular Biosciences said the team identified an antibody that improved survival rates in laboratory trials and reduced the presence of virus in the blood.
"We made a discovery in 2015 in the wake of the Zika outbreak that identified a new target for flavivirus treatments, a viral protein called NS1," Dr Watterson said.
PHILADELPHIA -- (Jan. 7, 2021) -- Scientists at The Wistar Institute characterized an inhibitor that targets acetate metabolism in cancer cells. Cancer cells use acetate metabolism to support tumor growth in conditions of low nutrient and oxygen availability. This molecule caused tumor growth inhibition and regression in preclinical studies, demonstrating the promise of this approach as a novel therapeutic strategy for solid tumors. Study results were published today in Cancer Research, a journal of the American Association for Cancer Research.
As the first doses of COVID-19 vaccines are being rolled out, it is still unclear whether enough Americans are willing to be vaccinated to allow the nation to return to normalcy. Many believe a key part of the equation lies in how effective vaccine communication teams are at convincing the public to get vaccinated. And the key to effective communication tactics in promoting the vaccines may lie in demonstrated behavioral economics and consumer behavior theory, experts say.
Engineering researchers have developed a new technique for eliminating particularly tough blood clots, using engineered nanodroplets and an ultrasound "drill" to break up the clots from the inside out. The technique has not yet gone through clinical testing. In vitro testing has shown promising results.
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INDIANAPOLIS-- Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center published promising findings today in the New England Journal of Medicine on preventing a common complication to lifesaving blood stem cell transplantation in leukemia.
Alexandria, Va., USA -- The COVID-19 pandemic has significantly impacted dental education and training. The study "COVID-19 and Dental and Dental Hygiene Students' Career Plans," published in the JDR Clinical & Translational Research (JDR CTR), examined the short-term impact of the COVID-19 pandemic on dental hygiene and dental students' career intentions.
In a large-scale study of electronic health records, Vanderbilt University Medical Center investigators have determined the prevalence of functional seizures and characterized comorbidities associated with them.
Functional seizures are sudden attacks or spasms that look like epileptic seizures but do not have the aberrant brain electrical patterns of epilepsy.
Patients and healthcare providers at the Princess Margaret Cancer Centre rated virtual care during COVID-19 as highly satisfactory overall for quality of care and convenience, while at the same time saving patients millions in costs.
Scientists at the University of Birmingham, UK, have shown that a novel low molecular weight dextran-sulphate, ILB® could play a key role in treating open angle glaucoma (OAG), a neurodegenerative disease that affects over 70 million people worldwide and causes irreversible blindness.
OAG develops slowly over many years. Excessive matrix deposition (fibrosis) within the eye's main fluid drainage site can lead to increased intraocular pressure (IOP), resulting in damage to the optic nerve.1
Stomach cancer, or gastric cancer, is a common gastrointestinal malignancy. Peritoneal metastasis occurs in a majority of patients with advanced stomach cancer and is considered as an aggressive disease with poor outcomes.
Patients with peritoneal metastasis are typically not eligible for curative surgery. Therefore, preoperative detection and diagnosis of peritoneal metastasis are critical to inform treatment decision-making and avoid unnecessary surgery.
What The Study Did: Changes in out-of-hospital cardiac arrests and fatalities in the Detroit area during the COVID-19 pandemic are compared with year-earlier events for the same period in this observational study.
Authors: Adrienne V. Nickles, M.P.H., of the Michigan Department of Health and Human Services in Lansing, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2020.32331)
Sophia Antipolis, 7 January 2021: Patients with acute heart failure nearly double their risk of dying if they get COVID-19, according to research published today in ESC Heart Failure, a journal of the European Society of Cardiology (ESC).1 The small, single centre study highlights the need for patients with heart failure to take extra precautions to avoid catching COVID-19.
WHO H. Gilbert Welch MD, MPH, Senior Investigator, Center for Surgery and Public Health, Brigham and Women's Hospital; co-author of a new Sounding Board article published in The New England Journal of Medicine.
CLEVELAND - In a new paper, researchers describe their development of a near-real time spatial assessment of COVID-19 cases to help guide local medical responses to clusters of outbreaks of the virus at the local level.
The paper, entitled "Geographic monitoring for early disease detection (GeoMEDD)," appeared in the Dec. 10 issue of Nature Scientific Reports and comes from researchers at Case Western Reserve University (CWRU) School of Medicine, University Hospitals (UH) Cleveland Medical Center, and Texas A & M University.