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Chinese scientists have made direct observations in face-centered cubic VCoNi (medium)-entropy alloys (MEA) and for the first time proposed a convincing identification of subnanoscale chemical short-range order (CSRO). This achievement undisputedly resolves the pressing question of if, what and why CSRO exists, and how to explicitly identify CSRO.

Models that can successfully predict suicides in a general population sample can perform poorly in some racial or ethnic groups, according to a study by Kaiser Permanente researchers published April 28 in JAMA Psychiatry.

For the first time, scientists are able to study changes in the DNA of any human tissue, following the resolution of long-standing technical challenges by scientists at the Wellcome Sanger Institute. The new method, called nanorate sequencing (NanoSeq), makes it possible to study how genetic changes occur in human tissues with unprecedented accuracy.

With the publication of 16 high-quality reference genomes from across vertebrates, the project establishes standards for biodiversity genomics and reports discoveries in comparative biology, conservation, and health research.

Enhancing the brain's lymphatic system when administering immunotherapies may lead to better clinical outcomes for Alzheimer's disease patients, according to a new study in mice. Results published April 28 in Nature suggest that treatments such as the immunotherapies BAN2401 or aducanumab might be more effective when the brain's lymphatic system can better drain the amyloid-beta protein that accumulates in the brains of those living with Alzheimer's.

What The Study Did: The association between undergoing gender-affirming surgery and mental health outcomes was looked at in this study.

What The Study Did: Researchers evaluated racial/ethnic differences in the performance of statistical models that use health record data to predict the risk of suicide after an outpatient mental health visit.

What The Study Did: The number of applicants and number of applications submitted per applicant to internal medicine residency and subspecialty fellowships for 2021 during the COVID-19 pandemic were compared with five prior application cycles in this study.

What The Study Did: Length, readability and complexity of informed consent documents for the COVID-19 vaccine phase III randomized clinical trials were assessed in this quality improvement study.

Is forest harvesting increasing in Europe? Yes, but not as much as reported last July in a controversial study published in Nature.Forest harvest has increased by just 6% in recent years, not 69% as reported by the European Commission's Joint Research Centre. The errors are due to satellite sensitivity and natural disturbances according to a response paper authored by 30 scientists from 13 European countries.

Researchers at Washington University School of Medicine in St. Louis have found that improving the function of the brain's drainage network, known as the meningeal lymphatics, can make certain experimental Alzheimer's therapies more effective in mice.

Childhood exposure to air pollution, such as nitrogen oxides and fine particulate matter, is a risk factor for mental illness at age 18. It is less of a factor than family history, but equal to lead. The finding comes from a cohort of 2,000 twins born in England and Wales in 1994-1995 and followed to young adulthood.

Across fruit flies, rodents and humans, levels of glutamate transporter in dopamine neurons determine the individual's vulnerability to age-related neurologic disorders.

Being able to build and control systems of quantum particles, which are among the smallest objects in the universe, is the key to developing quantum technology. That goal is now a step closer thanks to University of Chicago scientist Cheng Chin, who just figured out how to bring multiple molecules at once into a single quantum state--one of the most important goals in quantum physics.

A bold project to read the complete genetic sequences of every known vertebrate species reaches its first milestone by publishing new methods and the first 25 high-quality genomes.

UC Davis researchers develop PsychLight, a sensor that could be used in discovering new treatments for mental illness, in neuroscience research and to detect drugs of abuse.

Psychedelic drugs have shown promise for treating neuropsychiatric disorders like depression and posttraumatic stress disorder. However, due to their hallucinatory side effects, some researchers are trying to identify drugs that could offer the benefits of psychedelics without causing hallucinations. In the journal Cell on April 28, researchers report they have identified one such drug through the development of a genetically encoded fluorescent sensor--called psychLight--that can screen for hallucinogenic potential.

The neurotransmitter noradrenaline, which plays a key role in the fight-or-flight stress response, impairs immune responses by inhibiting the movements of various white blood cells in different tissues, researchers report April 28th in the journal Immunity. The fast and transient effect occurred in mice with infections and cancer, but for now, it's unclear whether the findings generalize to humans with various health conditions.

The research team led by Prof. WENG Jianping from University of Science and Technology of China (USTC) of the Chinese Academy of Sciences has implemented a comprehensive preconception-to-pregnancy management plan, namely CARNATION study, for women with type 1 diabetes (T1D), to reduce the risks of adverse pregnancy outcomes and improve the pregnancy care since 2015. The study was published in Diabetes Care.

A new study with the University of Copenhagen represented indicates that the coronavirus variant called P.1, which originated in Brazil, could pose a bigger threat than previously assumed. The researchers conclude that it is likely that P.1 is more transmissible than other strains of SARS-Cov2 and that might be able to evade immunity gained from previous infection with coronavirus.