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Scientists at Sanford Burnham Prebys Medical Discovery Institute have taken a deep dive into a previously overlooked family of proteins and discovered that they are essential to maintaining the energy that cells need to grow and survive. The proteins, known as lipid kinases, produce messengers that help balance cellular metabolism and promote overall health. The findings, published in Developmental Cell, provide further support to pursue lipid kinases as promising therapeutic targets for diseases that demand excess energy, such as cancer.

MD Anderson researchers have discovered a new role for the DHODH enzyme in blocking a form of cell death called ferroptosis. Preclinical findings suggest that targeting DHODH could restore cell death and inhibit tumor growth.

What The Study Did: Delayed localized injection-site reactions to the Moderna COVID-19 vaccine for 16 patients are described in this report.

What The Study Did: Researchers used registry data to examine the number, characteristics and outcomes of patients with sunburns severe enough to warrant admission to specialist burn services in Australia and New Zealand.

What The Study Did: This survey study estimated the number of children and adolescents in the United States who have received medical care as a result of assault, abuse or exposure to violence.

What The Study Did: Rates of preterm birth and stillbirth in Ontario, Canada, during the first six months of the COVID-19 pandemic are evaluated in this study.

What The Study Did: Researchers describe overdose deaths in San Francisco before and after the initial COVID-19 shelter-in-place order to try to make clear whether characteristics of fatal overdoses changed during this time in an effort to guide future prevention efforts.

Artificial intelligence, interpreting data from a device placed at the brain's surface, enables people who are paralyzed or have severely impaired limb movement to communicate by text.

Scientists have for the first time revealed the structure surrounding important receptors in the brain's hippocampus, the seat of memory and learning. The new study focuses on the organization and function of glutamate receptors, a type of neurotransmitter receptor involved in sensing signals between nerve cells in the hippocampus region of the brain. The study reveals the molecular structure of three major complexes of glutamate receptors in the hippocampus.

Using a brain-computer interface, a clinical trial participant was able to create text on a computer at a rate of 90 characters per minute just by thinking about the movements involved in writing by hand.

Researchers have, for the first time, decoded the neural signals associated with writing letters, then displayed typed versions of these letters in real time. They hope their invention could one day help people with paralysis communicate.

A joint team at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and Tsinghua University recently investigated the molecular mechanism by which the ZAR1 resistosome activates plant immunity.

University of Chicago Asst. Prof. Mark Levin and his team have discovered a way to create new molecules by cutting nitrogen atoms from molecules.

An enzyme could make a dream come true for the energy industry: It can efficiently produce hydrogen using electricity and can also generate electricity from hydrogen. The enzyme is protected by embedding it in a polymer. An international research team with significant participation of scientists from Technical University of Munich (TUM) has presented the system in the renowned science journal Nature Catalysis.

A new, patented method called Progressive Mechanoporation makes it possible to mechanically disrupt the membranes of cells for a short time period and let drugs or genes inside cells. In this way, researchers can test new therapies more easily than before.

Scientists have identified the fossil of a giant mosasaur in Morocco that grew up to 8 metres long.

A team of researchers at the Centre for Cognitive Science at TU Darmstadt has developed a computer font that adapts its appearance based on the user's interaction with the text. "AdaptiFont" measures a user's reading speed and interactively changes the font's shape seamlessly and continuously to allow the user to read text more easily. By employing an artificial intelligence algorithm, new personalized fonts are generated on the fly in such a way that they increase an individual reader's reading speed.

Researchers from the ECRC in Berlin, together with scientists from the United States and Canada, have discovered a sugar molecule whose levels are reduced in the blood of patients with particularly severe multiple sclerosis. Their discovery could pave the way for a new therapeutic approach, the team reports in medical journal JAMA Neurology.

Researchers at the Francis Crick Institute and the Latvian Institute of Organic Synthesis have designed a drug-like compound which effectively blocks a critical step in the malaria parasite life cycle and are working to develop this compound into a potential first of its kind malaria treatment.

Researchers from the National University of Singapore have created a new class of intelligent materials. It has the structure of a two-dimensional (2D) material, but behaves like an electrolyte - and could be a new way to deliver drugs within the body.