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An international and multidisciplinary team led by researchers at the University of Oxford, University of Glasgow, and University of Heidelberg, has uncovered the interactions that SARS-CoV-2 RNA establishes with the host cell, many of which are fundamental for infection. These discoveries pave the way for the development of new therapeutic strategies for COVID-19 with broad-range antiviral potential.

The research team of Gero, a Singapore-based biotech company in collaboration with Roswell Park Comprehensive Cancer Center in Buffalo NY, announces a publication in Nature Communications, a journal of Nature portfolio, presenting the results of the study on associations between aging and the loss of the ability to recover from stresses.

A new study from Washington University School of Medicine in St. Louis suggests that, among men, low testosterone levels in the blood are linked to more severe COVID-19. The study contradicts widespread assumptions that higher testosterone may explain why men, on average, develop more severe COVID-19 than women do.

What The Study Did: Rates of depression, anxiety, suicidal thoughts and posttraumatic stress disorder among current and former coal miners in the United States were examined in this study.

What The Study Did: Researchers examined if circulating sex hormones are associated with disease severity in patients with COVID-19.

What The Study Did: This study evaluates the association between bitter taste receptor types (supertasters who experience greater intensity of bitter tastes; tasters; and nontasters who experience low intensity of bitter tastes or no bitter tastes) and outcomes after infection with SARS-CoV-2.

As antibiotic-resistant bacteria become more prevalent, silver has seen steep growth in its use in things like antibacterial coatings. Still, a better understanding can provide clues on how to best apply it. In Chemical Physics Reviews, researchers monitored the interaction of silver nanoparticles with a nearby E. coli culture and found the silver undergoes several dramatic changes. Most notably, the E. coli cells caused substantial transformations in the size and shape of the silver particles.

Bottom Line: In a new recommendation statement, the U.S. Preventive Services Task Force (USPSTF) recommends that clinicians offer pregnant adolescents and adults effective behavioral counseling interventions aimed at promoting healthy weight gain and preventing excess gestational weight gain in pregnancy.

Alzheimer's disease is the main cause of dementia and current therapeutic strategies cannot prevent, slow down or cure the pathology. The disease is characterized by memory loss, caused by the degeneration and death of neuronal cells in several regions of the brain, including the hippocampus. Researchers from the Netherlands Institute for Neuroscience have identified a small molecule that can be used to rejuvenate the brain and counteract the memory loss.

Scientists from the University of Bath in the UK explore racemases and propose strategies for finding drugs that target these important enzymes.

New effective compounds, which can be endogenous donors of a signaling molecule - hydrogen sulfide in the body, were synthesized by SUSU scientists. Due to this property, the obtained compounds are potential drugs with a cancer-preventing effect. The research work was published in the Russian Chemical Bulletin (Q3).

To improve the development of new saliva-based diagnostic tests and personalized medicine, the National Institute of Dental and Craniofacial Research (NIDCR) has supported the development of the Human Salivary Proteome Wiki, the first public platform that catalogs and curates data on each of the thousands of proteins within our saliva.

Cells sense and respond to the mechanical properties of the cellular microenvironment in the body. Changes in these properties, which occur in a number of human pathologies, including cancer, can elicit abnormal responses from cells. How the cells adapt to such changes in the mechanical microenvironment is not well understood.

New research led by UCF assistant professor of management Jeff Gish suggests that engaging in recovery may help entrepreneurs reduce the negative impact of stress.

In the latest National Autism Indicators Report, researchers from Drexel University's A.J. Drexel Autism Institute found families of autistic adults who use Developmental Disability services face gaps in services and supports, lack of emergency planning and barriers to community participation.

Scientists at Empa and EPFL have identified a new type of defect as the most common source of disorder in on-surface synthesized graphene nanoribbons, a novel class of carbon-based materials that may prove extremely useful in next-generation electronic devices. The researchers identified the atomic structure of these so-called "bite" defects and investigated their effect on quantum electronic transport. These kinds of defective zigzag-edged nanoribbons may provide suitable platforms for certain applications in spintronics.

A rare mutation that causes Parkinson's disease-like symptoms interrupts the flow of dopamine in the brain, suggests a study in fruit flies published today in eLife.

Researchers from University of Copenhagen have investigated what happened to a specific kind of plasma - the first matter ever to be present - during the first microsecond of Big Bang. Their findings provide a piece of the puzzle to the evolution of the universe, as we know it today.

When it comes to distinguishing a healthy cell from an infected one that needs to be destroyed, the immune system's killer T cells sometimes make mistakes.

Graphene is an ultrathin material characterized by its ultrasmall bending modulus, superflimsiness. Now the researchers at the Nanoscience Center of the University of Jyväskylä have demonstrated how an experimental technique called optical forging can make graphene ultrastiff, increase its stiffness by several orders of magnitude. The research was published in Nature Partner Journals in May 2021.