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In the international prospective multicenter crossover LEADER-75 trial, comparison of reduced-dose gadobutrol and standard-dose gadoterate versus unenhanced imaging demonstrated noninferiority using 20% margin for three primary efficacy measures; mean readings differed by less than 1%, supporting equivalence using a narrow ±5% margin. Various secondary variables also supported non-inferiority of reduced-dose gadobutrol.

An algorithm designed by researchers from Carnegie Mellon University's Computational Biology Department and St. Petersburg State University in Russia could help scientists identify unknown molecules. The algorithm, called MolDiscovery, uses mass spectrometry data from molecules to predict the identity of unknown substances, telling scientists early in their research whether they have stumbled on something new or merely rediscovered something already known. This development could save time and money in the search for new naturally occurring products that could be used in medicine.

In a bid to find or refine laboratory research models for cancer that better compare with what happens in living people, Johns Hopkins Medicine scientists report they have developed a new computer-based technique showing that human cancer cells grown in culture dishes are the least genetically similar to their human sources.

UC San Diego School of Medicine researchers discovered that the enzyme RNA polymerase II recognizes and transcribes artificially added base pairs in genetic code, a new insight that could help advance the development of new vaccines and medicines.

Forest fires have crept higher up mountains over the past few decades, scorching areas previously too wet to burn, according to researchers from McGill University. As wildfires advance uphill, a staggering 11% of all Western US forests are now at risk.

Patients with blood cancers who were hospitalized with COVID-19 fared better if they were given convalescent plasma, according to study findings from a consortium that included the Mays Cancer Center, home to UT Health San Antonio MD Anderson.

Geothermal energy systems have the potential to power the world and become the leading technology for reducing greenhouse gas emissions if we can drill down far enough into the Earth to access the conditions necessary for economic viability and release the heat beneath our feet. Quaise Inc. is developing a potentially disruptive drilling technology to make that happen. Matt Houde of Quaise presented the approach at the World Geothermal Congress on June 15.

Additive manufacturing offers an unprecedented level of design flexibility and expanded functionality, but the quality and process can drastically differ across production machines, according to Hui Yang, a professor of industrial engineering at Penn State. With applications in aerospace, health care and automotive industries with potential for mass customization, additive manufacturing needs quality management.

By cleverly combining complementary sequencing techniques, researchers of Ghent University, together with Baylor College of Medicine and the world's leading sequencing company, Illumina, have deepened our understanding of the function of known RNA molecules and discovered thousands of new RNAs. A better understanding of our transcriptome is essential to better understand disease processes and uncover novel genes that may serve as therapeutic targets or biomarkers.

With sorghum poised to become an important crop grown by Pennsylvania farmers, Penn State researchers, in a new study, tested more than 150 germplasm lines of the plant for resistance to a fungus likely to hamper its production.

In research published today in Nature Nanotechnology, a team of materials scientists and engineers, led by Jian Shi, an associate professor of materials science and engineering at Rensselaer Polytechnic Institute, used a strain gradient in order to break inversion symmetry, creating a novel optoelectronic phenomenon in the promising material molybdenum disulfide (MoS2) -- for the first time.

Superconductors have tremendous appeal in power transmission applications due to their zero resistance. However, to bring classical metallic superconductors into superconducting state requires liquid helium as a coolant, which is costly. Now, scientists from Japan take things to the new level by demonstrating high temperature superconductivity in mixed rare-earth barium copper oxides fabricated using a popular technique, opening doors to their low-cost, industrial scale production for real-world applications.

The Scientists Advocate Shifting the Current Value System, which is Biased Against Women and Minorities, Towards a More Diverse and Inclusive Model of Science

Researchers from Bentley University, in partnership with Waltham Council on Aging in Massachusetts, and as part of a study funded by the National Science Foundation, have been exploring how the elderly use smart speakers at home.

KIYATEC announces clinical study data showing test accurately predicts brain cancer patient response to standard drug therapy prior to treatment.

Nanodecoys made from human lung spheroid cells (LSCs) can bind to and neutralize SARS-CoV-2, promoting viral clearance and reducing lung injury in a macaque model of COVID-19. By mimicking the receptor that the virus binds to rather than targeting the virus itself, nanodecoy therapy could remain effective against emerging variants of the virus.

A research team from Los Alamos National Laboratory and Purdue University have developed bio-inks for biosensors that could help localize critical regions in tissues and organs during surgical operations.

Scientists from The University of Texas Health Science Center at San Antonio and collaborating institutions found no associations of depressive symptoms with amyloid beta protein deposition in a study of middle-aged Framingham Heart Study participants. They did, however, note an association of tau protein aggregates with depressive symptoms in subjects carrying a genetic variant called APOE e4.

Woodlands along streams and rivers are an important part of California's diverse ecology. They are biodiversity hotspots, providing various ecosystem services including carbon sequestration and critical habitat for threatened and endangered species. But our land and water use have significantly impacted these ecosystems, sometimes in unexpected ways.

Babies born by cesarean section don't have the same healthy bacteria as those born vaginally, but a Rutgers-led study for the first time finds that these natural bacteria can be restored.