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Daunting and uncertain is the future for people who must decide whether, where, when, and how to vacate their homes as the climate changes.

Patents with all-female inventor teams are more likely than all-male teams to address problems that specifically or disproportionately affect women, according to a new study.

A new treatment approach focused on fixing cell damage, rather than fighting the virus directly, is effective against SARS-CoV-2 in lab models. Combination of two drugs reduces spread of SARS-CoV-2 infection in cells by up to 99.5%.If found safe for human use, this anti-viral treatment would make COVID-19 symptoms milder and speed up recovery times.

The yellow fever mosquito (scientific name, Aedes aegypti) spreads multiple untreatable viruses in humans and is primarily controlled using a pesticide called permethrin. However, many mosquitoes are evolving resistance to the pesticide. A new study by Karla Saavedra-Rodriguez of Colorado State University and colleagues, published in the journal PLOS Genetics, identifies mutations linked to different permethrin resistance strategies, which threaten our ability to control disease outbreaks.

Current approaches for planning relocation for potentially millions of people affected by climate change are 'woefully inadequate' and risk worsening societal inequities, experts wrote in a policy perspective on June 17 in Science. Policymakers and scientists need to rethink how they work together to develop, communicate and carry out relocation plans so that relocating communities can thrive, though it relies on a transformation in how science is used, tools are deployed, and stakeholders are engaged.

Pertussis, also known as "whooping cough," remains a significant cause of death in infants and young children around the world and, despite global vaccination programs, many countries are experiencing a resurgence of this highly contagious disease. A new study by Boston University School of Public Health and the University of Georgia's Odum School of Ecology presents evidence that could help explain this resurgence: asymptomatic individuals. Lots of them.

An intrauterine fracture is a rare finding during routine prenatal imaging. This condition can be due to maternal trauma, genetic disorders of the skeleton, as well as other predisposing maternal metabolic and vascular disorders. Genetic disorders that have previously been reported to cause intrauterine fracture include brittle bone disease (osteogenesis imperfecta or OI), osteopetrosis, hypophosphatasia and Ehlers-Danlos syndrome (EDS).

Adding an immune checkpoint inhibitor to anti-HER2 treatment in breast cancer does not improve pathological complete response (pCR), according to the primary analysis of the IMpassion050 trial presented today during the ESMO Virtual Plenary. The phase III trial is the first to report data comparing a neoadjuvant anti-HER2 based regimen with or without the anti-PD-L1 antibody atezolizumab in patients with high-risk, HER2-positive early breast cancer.

The glaciers of Nanga Parbat - one of the highest mountains in the world - have been shrinking slightly but continually since the 1930s. This loss in surface area is evidenced by a long-term study of Heidelberg University. The geographers combined historical photographs, surveys, and topographical maps with current data, which allowed them to show glacial changes for this massif in the north-western Himalaya as far back as the mid-1800s.

Chemical engineers at the University of Illinois Chicago and UCLA have answered longstanding questions about the underlying processes that determine the life cycle of liquid foams. The breakthrough could help improve the commercial production and application of foams in a broad range of industries.

A new study led by Mohamad Ali-Dib, a research scientist at the NYU Abu Dhabi Center for Astro, Particle, and Planetary Physics, reports the significant discovery that two groups of TNOs with different surface colors also have very different orbital patterns. This new information can be compared to models of the solar system to provide fresh insights into its early chemistry.

The German National Academy of Sciences Leopoldina and the German Council for Sustainable Development (RNE) have published a joint position paper presenting paths to climate neutrality by 2050. In it, the Leopoldina and the RNE highlight options for action to effect the changes needed within society, at political level and in the business world, in view especially of the urgency and the historic dimensions of the transformation we face.

Researchers at the MDC, the BIH and Charité have developed methods for performing comprehensive analyses of fixed tumor tissue samples. These analyses make it possible to shed new light on the clinical course of various cancer types, as the team reports in "Nature Communications".

A study performed by researchers at the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) from the Spanish National Research Council (CSIC) in collaboration with Stony Brook University (USA) proposes a new strategy for the development of new drugs based on the inhibition of tyrosine kinase enzymes, molecules that activate and trigger many cellular processes. The results have been published in the Chemistry - A European Journal.

Researchers from Tokyo Medical and Dental University (TMDU) have found that the urinary secretion of uromodulin, a kidney-specific protein, can be increased by the hormone vasopressin via certain signaling pathways. Increasing the urinary secretion of uromodulin may protect against urinary tract infections and kidney stones, while the resulting lower uromodulin levels in kidney cells may help to prevent hypertension and chronic kidney disease.

RUDN University biotechnologists have created a method for detection of bacterial infection in apple, pear, hawthorn and other plants of the Rosaceae family. The test does not require laboratory equipment, the result is ready in 10 minutes. This will allow detecting the disease quickly and prevent the spread of infection.

DNA analysis has revealed the presence of 'Yersinia Pestis' - the pathogen that causes plague - in skeletal remains from individual burials in medieval Cambridgeshire, confirming for the first time that not all plague victims were buried in mass graves. Compassion and care were shown to victims even during traumatic times during past pandemics.

Modelling the financial system as a network is a precondition to understanding and managing the containment of financial crises and the transition to a low-carbon economy. Financial Networks is the scientific discipline that deals with these issues. An article published in the scientific journal Nature Review Physics carries out the first comprehensive review of this field.

An international research consortium, in which Inselspital, Bern University Hospital and the University of Bern participated, has re-assessed and updated the previous classification of metastatic testicular cancer in a comprehensive study. New indicators and a much broader database enabled a more precise classification and more targeted treatments of patients. In addition, the new data show that the prognosis for patients with metastatic testicular cancer has improved significantly over the past twenty years.

Chronic stress could be one reason why some animal orphans have shorter lives and less offspring. Researchers from the Max Planck Institute for Evolutionary Anthropology in Leipzig and the Institute of Cognitive Sciences, CNRS in Lyon assessed if, as orphan humans, orphan chimpanzees are exposed to chronic stress. They found that maternal loss is stressful but orphans experience little chronic stress since stress hormones return to normal after two years, possibly thanks to care provided by other chimpanzees.