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New epigenetic regulatory mechanisms involved in multiple myeloma growth
An international team of researchers has analyzed the function of the histone demethylase KDM5A in multiple myeloma, one of the three major hematological cancers, and clarified the mechanism by which it promotes myeloma cell proliferation. They also developed a novel KDM5 inhibitor and showed that it inhibits cancer cell growth in a myeloma mouse model. The researchers expect that new therapies targeting KDM5A will be developed in the future.
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COVID-19 vaccination: Thrombosis can be prevented by prompt treatment
A rare syndrome has been observed in people following vaccination against Covid-19. This involves thrombosis at unusual sites in the body, associated with a low thrombocyte count and a clotting disorder. In medical jargon, this syndrome is referred to as VITT (vaccine-induced thrombotic thrombocytopenia). Doctors at MedUni Vienna and Vienna General Hospital have now successfully treated an acute instance of this syndrome.
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Oncotarget: Phase 1 study of Z-Endoxifen in patients with solid tumors
The Oncotarget article provides evidence that antitumor activity and prolonged stable disease are achieved with Z-endoxifen despite prior tamoxifen therapy.
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Oncotarget: CABYR-a/b and CABYR-c hold promise as targets for specific immunotherapy
CABYR expression in tumors was further confirmed by immunohistochemistry
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Stair climbing offers significant cardiovascular and muscular benefits for heart patients
A team of McMaster University researchers who studied heart patients found that stair-climbing routines, whether vigorous or moderate, provide significant cardiovascular and muscular benefits.
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Oncotarget: Caloric restriction creates a metabolic pattern of chronological aging delay
The Oncotarget authors propose a model of how the specific remodeling of cellular metabolism by caloric restriction contributes to yeast chronological aging delay.
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US nurses working in critical care have been severely impacted by the COVID-19 pandemic
The COVID-19 pandemic has, and will continue to have, a tremendous impact on ICU nurses' mental health and willingness to continue in the critical care work force, according to research presented at the ATS 2021 International Conference.
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New numerical method makes simulating landslide tsunamis possible
Researchers from Tohoku University have developed a new numerical method that paves the way for simulating landslide tsunamis.
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Global land use more extensive than estimated
Humans leave their "footprints" on the land area all around the globe. These land-use changes play an important role for nutrition, climate, and biodiversity. Scientists at the Karlsruhe Institute of Technology (KIT) combined satellite data with statistics from the past 60 years and found that global land-use changes affect about 32 percent of the land area. This means that they are about four times as extensive as previously estimated. The researchers publish their findings in the scientific journal Nature Communications.
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Engineered organism could diagnose Crohn's disease flareups
Rice University researchers have engineered a bacterium capable of diagnosing a human disease, a milestone in the field of synthetic biology.
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Mechanics of the infinitely small: NanoGear, towards a molecular gear
Oscillatory and rotational motions of different parts are combined in a newly conceived artificial molecule, paving the way for the construction of devices capable of transforming and transmitting movements on the nanometer scale. The nanodevice was designed, synthesized and tested by a team of researchers of the University of Bologna
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New study finds combination of Omega-3s in popular supplements may blunt heart benefits
New research from the Intermountain Healthcare Heart Institute in Salt Lake City finds that higher EPA blood levels alone lowered the risk of major cardiac events and death in patients, while DHA blunted the cardiovascular benefits of EPA. Higher DHA levels at any level of EPA, worsened health outcomes.
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Scientists explore Tesla roads not taken -- and find new potential present-day utility
A valve invented by engineer Nikola Tesla a century ago is not only more functional than previously realized, but also has other potential applications today, a team of researchers has found after conducting a series of experiments on replications of the early 20th-century design.
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Prenatal detection of heart defects lower in rural, poor areas and among Hispanic women
Living in rural areas, neighborhoods with lower socioeconomic levels or being of Hispanic ethnicity are associated with lower prenatal detection and later diagnosis of a congenital heart defect known as transposition of the great arteries.Similarly, living in neighborhoods with lower socioeconomic levels was linked with decreased detection of a condition known as hypoplastic left heart syndrome, another type of congenital heart defect.
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New study of how US recreational cannabis legalization could change illegal drug markets
A study published in the scientific journal Addiction provides the most comprehensive evidence to date of the association between recreational cannabis laws (RCLs) in US states and responses in the illegal markets for cannabis, heroin, and other drugs in those states.
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Save our oceans to protect our health - scientists call for global action plan
An interdisciplinary European collaboration called the Seas Oceans and Public Health In Europe (SOPHIE) Project, led by the University of Exeter and funded by Horizons 2020, has outlined the initial steps that a wide range of organisations could take to work together to protect the largest connected ecoInsystem on Earth. They call for the current UN Ocean Decade to act as a meaningful catalyst for global change, reminding us that ocean health is intricately linked to human health.
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Shortcut for dendritic cells
During an inflammatory response, things need to happen quickly: ETH Zurich researchers have recently discovered that certain immune cells that function as security guards can use a shortcut to get from the tissue to lymph nodes.
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The incredible return of Griffon Vulture to Bulgaria's Eastern Balkan Mountains
Considered extinct from the Eastern Balkan Mountains of Bulgaria in the 1970s, the Griffon Vulture has claimed the area back with 23-25 breeding pairs, distributed in five different colonies and two more frequently used roosting sites. This astonishing success was achieved through an ambitious long-term restoration programme and the release of 153 vultures between 2010-2020. The research project is described in the open-access, peer-reviewed Biodiversity Data Journal.
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How plankton hold secrets to preventing pandemics
Whether it's plankton exposed to parasites or people exposed to pathogens, a host's initial immune response plays an integral role in determining whether infection occurs and to what degree it spreads within a population, new University of Colorado Boulder research suggests.
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Preemie boys age faster as men, study shows
Using an epigenetic clock, the researchers looked at the genes of 45 of those who were ELBW babies along with 47 who were normal birth weight when they were age 30 to 35 to compare their biological age, controlling for chronic health problems and sensory impairments.
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