A new SLAS Discovery review article by GlaxoSmithKline researchers in the U.S. and U.K. offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.

Every cell in the body contains thousands of different protein molecules and they can change this composition whenever they are induced to perform a particular task or convert into a different cell type. Understanding how cells function depends on proteomics, the ability to measure all of the changes in a cell's protein components.

New Rochelle, NY, June 13, 2018 -- Researchers have demonstrated that a novel biocompatible adhesive made of two naturally derived polymers is 15 times stronger than adhesive materials currently used for nerve reconstruction and can support the survival, extension, and proliferation of cells essential for nerve regeneration.

A recent study published in American Psychiatric Association's Psychiatric Services journal found previous research on youth hospitalizations associated with behavioral and mental disorders failed to adequately consider children exhibiting suicidality or self-harm. Previous studies assigned behavioral health disorders, such as depression, as the primary diagnosis, while identifying suicidality or self-harm as a secondary diagnosis.

Minneapolis, June 14, 2018 - Having a prior cesarean section (C-section), smoking, illicit drug use, and obesity increase the likelihood of developing an infection during a C-section delivery, according to new research presented at the 45th Annual Conference of the Association for Professionals in Infection Control and Epidemiology (APIC).

Minneapolis, June 14, 2018 - Neonatal intensive care units increasingly encourage meaningful touch and skin-to-skin care - aka "kangaroo care" - between parents and premature babies to aid the babies' development. But a Michigan children's hospital practicing skin-to-skin care noticed an unwanted side effect in 2016 - a spike in Staphylococcus aureus (SA) infections among newborns.

Bottom Line: Parents of adolescents believed that the potential to prevent certain types of cancer is the best reason for their children to receive the human papillomavirus (HPV) vaccine, whereas other reasons health care providers often give were far less persuasive.

Journal in Which the Study was Published: Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

In a collaborative study involving Equal Channel Angular Extrusion (ECAE), a unique severe plastic deformation (SPD) process, researchers Dr. Ibrahim Karaman from Texas A&M University and Drs. Don Susan and Andrew Kustas of Sandia National Laboratories were able to improve the mechanical properties of magnetic alloys without changing their magnetic properties through microstructural refinement. This process has proven to be troublesome in the past.

A research team at the São Paulo State University's Bioscience Institute (IB-UNESP) in Rio Claro, Brazil, has identified 29 fungi with proven action against Xanthomonas citri, a bacterium responsible for citrus canker, an endemic disease in all citrus-producing countries. The origin of the fungi is surprising. They were isolated from samples of soil and marine sediment collected in Antarctica.

Irvine, Calif., June 13, 2018 - El Niño was long considered a reliable tool for predicting future precipitation in the southwestern United States, but its forecasting power has diminished in recent cycles, possibly due to global climate change. In a study published today in Nature Communications, scientists and engineers at the University of California, Irvine demonstrate a new method for projecting wet or dry weather in the winter ahead.