BIRMINGHAM, Ala. - The more than 200 different types of human cells have the same DNA but express different ensembles of genes. Each cell type was derived from embryonic stem cells, which are called pluripotent stem cells because they can differentiate to all those different cell fates.
One very active area of biology is cells that mimic these fountainhead embryonic stem cells, cells that are called induced pluripotent stem cells, or iPSCs. With genetic and biochemical tricks, researchers can reverse a differentiated cell -- such as a skin fibroblast -- into a pluripotent state.
Researchers are calling for a randomised clinical trial to investigate the potential role of vitamin D supplementation in improving live birth rates following assisted reproduction treatment (ART).
This follows a review and meta-analysis published today in Human Reproduction, which shows a strong link between low vitamin D concentrations in women and lower live birth rates after ART compared to women who have the right amount of vitamin D in their bodies.
The UK charity "Association for the Study of Obesity" (ASO) is dedicated to the prevention and treatment of obesity. The ASO accepts that economic pressures influence the funding of treatment in the modern NHS. It must also be acknowledged that as the annual Organisation for Economic Cooperation and Development (OECD) Health at a Glance report shows, the UK has the highest obesity rate in western Europe.
INDIANAPOLIS -- A growing number of individuals of all ages are surviving intensive care unit hospitalization, however their mental and physical health problems persist. A new study from Regenstrief Institute and Indiana University researchers reports that a care model they originally developed for older adults with dementia could benefit ICU survivors of all ages.
Even with pre-operative imaging techniques, surgeons still rely on visual inspection to locate malignant tissues during surgery. New research released today at the 2017 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition may help surgeons better view and treat these tumor cells with engineered naphthalocyanine-based nanoparticles (SiNc-PNP) injected 24 hours before surgery, which then light up when they connect with the cancerous tumors.
PHILADELPHIA - People with psoriasis are at a higher risk to develop type 2 diabetes than those without psoriasis, and the risk increases dramatically based on the severity of the disease. Researchers from the Perelman School of Medicine at the University of Pennsylvania found people with psoriasis that covers 10 percent of their body or more are 64 percent more likely to develop diabetes than those without psoriasis, independent of traditional risk factors such as body weight.
COLUMBUS, Ohio - An anti-inflammatory drug may have the potential to stall the damaging effects of alcohol on the fetal brain, a new study suggests.
Ibuprofen reduced neuroinflammation and behavioral signs of alcohol exposure in a rat model of fetal alcohol spectrum disorders (FASD).
The study was the first to directly link alcohol-induced inflammation in the hippocampus to cognitive impairment later in the life, said Derick Lindquist, senior author and a professor of psychology at The Ohio State University.
VANCOUVER, WASHINGTON (November 14, 2017) - Newly published research provides preclinical proof-of-concept for the ability of PRO 140, a humanized anti-CCR5 monoclonal antibody under development by CytoDyn Inc. (OTC.QB: CYDY), to effectively block the development of graft-versus-host disease (GvHD), a potentially lethal complication of bone marrow stem cell (BMSC) transplantation. CytoDyn is currently enrolling patients in a Phase 2 clinical trial with PRO 140 for the prevention of GvHD in leukemia patients undergoing BMSC transplantation.
Montreal, Nov. 14, 2017 -- Research has already shown that women who develop either diabetes or high blood pressure during pregnancy are at risk of getting type 2 diabetes, high blood pressure or heart disease years later. Now, a new study from a team at the Research Institute of the McGill University Health Centre (RI-MUHC) and McGill University shows that the risk of developing those conditions post pregnancy is drastically higher if the women had both diabetes and high blood pressure during pregnancy.
Heart attack increased the risk of vascular dementia by 35 per cent, and the risk remains elevated for up to 35 years after the heart attack.
This is the somewhat disheartening result of a registry-based study from the Department of Clinical Epidemiology at Aarhus University, which has just been published in the journal Circulation.